Polarity and Morphogenesis‐‐‐ the Planar Cell Polarity Pathway in Mammalian Embryogenesis
نویسندگان
چکیده
منابع مشابه
Coupling planar cell polarity signaling to morphogenesis.
Epithelial cells and other groups of cells acquire a polarity orthogonal to their apical-basal axes, referred to as Planar Cell Polarity (PCP). The process by which these cells become polarized requires a signaling pathway using Frizzled as a receptor. Responding cells sense cues from their environment that provide directional information, and they translate this information into cellular asymm...
متن کاملPlanar Polarity and Tissue Morphogenesis
Planar polarity is a global, tissue-level phenomenon that coordinates cell behavior in a two-dimensional plane. The Frizzled/planar cell polarity (PCP) and anterior-posterior (AP) patterning systems for planar polarity operate in a variety of cell types and provide direction to cells with different morphologies and behaviors. These two systems involve different sets of proteins but both use dir...
متن کاملThe planar polarity pathway
to the brain and receive high-order commands and inputs from it. That is, much of the planning, computation and execution of stereotypic arm movements are conducted within the arm neural system itself. Accordingly, natural-looking arm extension movements can be generated in amputated arms. This organization may be an optimal solution for the motor control of highly redundant flexible appendages...
متن کاملPolarity in mammalian epithelial morphogenesis.
Cell polarity is fundamental for the architecture and function of epithelial tissues. Epithelial polarization requires the intervention of several fundamental cell processes, whose integration in space and time is only starting to be elucidated. To understand what governs the building of epithelial tissues during development, it is essential to consider the polarization process in the context o...
متن کاملThe signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis
The apical-basal (AB) polarity and planar cell polarity (PCP) provide an animal cell population with different phenotypes during morphogenesis. However, how cells couple these two patterning systems remains unclear. Here we provide in vivo evidence that melanoma cell adhesion molecule (MCAM) coordinates AB polarity-driven lumenogenesis and c-Jun N-terminal kinase (JNK)/PCP-dependent ciliogenesi...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.308.2